Familial Intracranial Aneurysm (FIA)

The aim of this project is io identify the gene (or genes) associated with formation and rupture of intracranial aneurysm in families with multiple affected family members.


This is a large-scale investigation, conducted across 23 centres internationally, to identify regions on chromosomes that lead to the formation and potential rupture of intracranial aneurysms in the blood vessels of the brain. The study includes interviews and blood analysis from several hundred families from Australia, New Zealand, Canada and the United States who have two or more affected members with intracerebral aneurysms.

Recruitment of over 400 families (more than 3200 participants) was completed in 2007. Analyses of the results are ongoing. A grant to continue the study in another phase (FIAII) is currently under review.

Project Manager

Dr Colin Howe, Clinical Trials Research Unit (Australia/New Zealand region manager)