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The ulnar ratio as a sensitive and specific marker of acute inflammatory demyelinating polyneuropathy.

TitleThe ulnar ratio as a sensitive and specific marker of acute inflammatory demyelinating polyneuropathy.
Publication TypeJournal Article
Year of Publication2018
AuthorsAhdab, R, Noureldine, MHassan A, Mohammedi, K, Nader, M, Zouari, HG, Nordine, T, Créange, A, Lefaucheur, J-P, Ayache, SS
JournalClin Neurophysiol
Volume129
Issue8
Pagination1699-1703
Date Published08/2018
ISSN1872-8952
Abstract

OBJECTIVES: To explore the value of a novel sensory criterion, the ulnar ratio - defined as the SNAP amplitude of the palmar cutaneous (pUN) over that of the dorsal branch (dUN) of the ulnar nerve - as a predictor of Acute Inflammatory Demyelinating Polyneuropathy (AIDP).

METHODS: We prospectively included 22 patients with AIDP, 20 patients with diabetic peripheral neuropathy (DPN), and 18 controls. Eligible subjects underwent nerve conduction studies including, among others, the dUN, pUN, and sural nerve.

RESULTS: A sural sparing pattern was found in 72% of AIDP cases. The ulnar ratio was significantly lower in patients with AIDP compared to those with DPN or controls. The ROC curve area to discriminate AIDP (versus controls and diabetics together) was higher with the ulnar ratio and pUN compared to dUN. An ulnar ratio ≥ 0.78 seems to be the best threshold to rule out the diagnosis of AIDP, with a specificity of 100% and a sensitivity of 87%. The ulnar ratio was equally reliable in the subgroup of patients presenting within a week of symptoms onset.

CONCLUSION: The ulnar ratio is a highly sensitive and specific marker of AIDP and can help confirm the diagnosis when direct signs of demyelination are lacking.

SIGNIFICANCE: Incorporating specific sensory abnormalities, such as the ulnar ratio, in the electrodiagnostic criteria of AIDP could enhance their reliability.

DOI10.1016/j.clinph.2018.05.017
Alternate JournalClin Neurophysiol
PubMed ID29940481
English