02541nas a2200337   4500000000100000008004100001100001400042700001300056700001600069700001200085700001300097700001500110700001200125700001400137700001300151700001600164700001200180700001900192700001300211700001400224700001500238700001400253700001500267700001600282245007900298250001500377300001400392490000700406520173900413020005102152       2017                            d1 aHeeley E.1 aStapf C.1 aRobinson T.1 aHata J.1 aZhang S.1 aLindley R.1 aChen X.1 aDavies L.1 aArima H.1 aDelcourt C.1 aSato S.1 aAnderson Craig1 aZheng D.1 aHackett M1 aLavados P.1 aSalman R.1 aSandset E.1 aChalmers J.00aIntracerebral hemorrhage location and outcome among INTERACT2 participants  a2017/02/27  a1408-14140 v883 a<p>
OBJECTIVE: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. RESULTS: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (<!--=0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). CONCLUSION: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. CLINICALTRIALSGOV REGISTRATION: NCT00716079.-->
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