02353nas a2200265   4500000000100000008004100001100001200042700001200054700001600066700001300082700001600095700001200111700001900123700001300142700001400155700001500169700001100184700001600195245016500211250001500376300001200391490000700403520162600410020005102036       2016                            d1 aWang J.1 aWang X.1 aHirakawa Y.1 aArima H.1 aDelcourt C.1 aSato S.1 aAnderson Craig1 aZheng D.1 aCarcel C.1 aSandset E.1 aQiu M.1 aChalmers J.00aAdmission Heart Rate Predicts Poor Outcomes in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies  a2016/05/12  a1479-850 v473 a<p>
BACKGROUND AND PURPOSE: Faster heart rate predicts higher mortality in coronary heart disease and acute ischemic stroke, but its prognostic significance in intracerebral hemorrhage remains uncertain. We aimed to determine the effect of admission heart rate on clinical and imaging outcomes in patients with intracerebral hemorrhage. METHODS: A post hoc pooled analysis of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT 1 and 2). Clinical outcomes were mortality and modified Rankin Scale score at 90 days; and imaging outcome was absolute growth in hematoma volume during the initial 24 hours. Patients were divided into 4 categories according to baseline heart rate (&lt;65, 65-74, 75-84, and &gt;/=85 bpm) and analyzed using multivariable adjusted models with the lowest heart rate group as the reference. RESULTS: Of 3185 patients with available data, higher admission heart rate was associated with both mortality and worse modified Rankin Scale score: adjusted hazard ratio for heart rate (&gt;/=85 versus &lt;65 bpm) 1.50 (95% confidence interval, 1.07-2.11) and adjusted odds ratio 1.33 (95% confidence interval, 1.08-1.63), respectively (both P-trend &lt;0.05). There was no significant relationship between heart rate and absolute growth in hematoma volume (P-trend, 0.196). CONCLUSIONS: Higher admission heart rate is independently associated with death and poor functional outcome after acute intracerebral hemorrhage. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.
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  a1524-4628 (Electronic)<br/>0039-2499 (Linking)