TY - JOUR AU - Lear S. AU - Whittaker R. AU - Santo K. AU - Niessen L. AU - Stepien S. AU - Redfern J AU - Rodgers A AU - Islam S. AU - Farmer A. AU - Bobrow K. AU - Maddision R. AU - Dale L. AU - Lechner A. AU - Eapen Z. AU - Chow Clara AB -

INTRODUCTION: Text message interventions have been shown to be effective in prevention and management of several non-communicable disease risk factors. However, the extent to which their effects might vary in different participants and settings is uncertain. We aim to conduct a systematic review and individual participant data (IPD) meta-analysis of randomised clinical trials examining text message interventions aimed to prevent cardiovascular diseases (CVD) through modification of cardiovascular risk factors (CVRFs). METHODS AND ANALYSIS: Systematic review and IPD meta-analysis will be conducted according to Preferred Reporting Items for Systematic review and Meta-Analysis of IPD (PRISMA-IPD) guidelines. Electronic database of published studies (MEDLINE, EMBASE, PsycINFO and Cochrane Library) and international trial registries will be searched to identify relevant randomised clinical trials. Authors of studies meeting the inclusion criteria will be invited to join the IPD meta-analysis group and contribute study data to the common database. The primary outcome will be the difference between intervention and control groups in blood pressure at 6-month follow-up. Key secondary outcomes include effects on lipid parameters, body mass index, smoking levels and self-reported quality of life. If sufficient data is available, we will also analyse blood pressure and other secondary outcomes at 12 months. IPD meta-analysis will be performed using a one-step approach and modelling data simultaneously while accounting for the clustering of the participants within studies. This study will use the existing data to assess the effectiveness of text message-based interventions on CVRFs, the consistency of any effects by participant subgroups and across different healthcare settings. ETHICS AND DISSEMINATION: Ethical approval was obtained for the individual studies by the trial investigators from relevant local ethics committees. This study will include anonymised data for secondary analysis and investigators will be asked to check that this is consistent with their existing approvals. Results will be disseminated via scientific forums including peer-reviewed publications and presentations at international conferences. TRIAL REGISTRATION NUMBER: CRD42016033236.

AD - The George Institute for Global Health, Sydney, Australia.
Sydney Medical School, University of Sydney, Sydney, Australia.
Ludwig-Maximillian Universitat, Munich, Germany.
Oxford University, Oxford, UK.
University of Cape Town, South Africa.
The University of Auckland, Auckland, New Zealand.
Deakin University, Melbourne, Australia.
Diabetes Research Group, Ludwig-Maximilians University, Munich, Germany.
Liverpool School of Tropical Medicine, Liverpool, UK.
Johns Hopkins University, Baltimore, Maryland, USA.
Simon Fraser University and St. Paul's Hospital, Vancouver, British Columbia, Canada.
Duke Clinical Research Institute, Durham, North Carolina, USA. AN - 27798018 BT - BMJ Open CN - [IF]: 2.271 DP - NLM ET - 2016/11/01 J2 - BMJ open LA - Eng LB - AUS
CDV
FY17 M1 - 10 N1 - Chow, Clara K
Islam, Sheikh Mohammed Shariful
Farmer, Andrew
Bobrow, Kirsty
Maddision, Ralph
Whittaker, Robyn
Dale, Leila Pfaeffli
Lechner, Andreas
Niessen, Louis
Lear, Scott A
Eapen, Zubin J
Santo, Karla
Stepien, Sandrine
Redfern, Julie
Rodgers, Anthony
England
BMJ Open. 2016 Oct 17;6(10):e012723. doi: 10.1136/bmjopen-2016-012723. N2 -

INTRODUCTION: Text message interventions have been shown to be effective in prevention and management of several non-communicable disease risk factors. However, the extent to which their effects might vary in different participants and settings is uncertain. We aim to conduct a systematic review and individual participant data (IPD) meta-analysis of randomised clinical trials examining text message interventions aimed to prevent cardiovascular diseases (CVD) through modification of cardiovascular risk factors (CVRFs). METHODS AND ANALYSIS: Systematic review and IPD meta-analysis will be conducted according to Preferred Reporting Items for Systematic review and Meta-Analysis of IPD (PRISMA-IPD) guidelines. Electronic database of published studies (MEDLINE, EMBASE, PsycINFO and Cochrane Library) and international trial registries will be searched to identify relevant randomised clinical trials. Authors of studies meeting the inclusion criteria will be invited to join the IPD meta-analysis group and contribute study data to the common database. The primary outcome will be the difference between intervention and control groups in blood pressure at 6-month follow-up. Key secondary outcomes include effects on lipid parameters, body mass index, smoking levels and self-reported quality of life. If sufficient data is available, we will also analyse blood pressure and other secondary outcomes at 12 months. IPD meta-analysis will be performed using a one-step approach and modelling data simultaneously while accounting for the clustering of the participants within studies. This study will use the existing data to assess the effectiveness of text message-based interventions on CVRFs, the consistency of any effects by participant subgroups and across different healthcare settings. ETHICS AND DISSEMINATION: Ethical approval was obtained for the individual studies by the trial investigators from relevant local ethics committees. This study will include anonymised data for secondary analysis and investigators will be asked to check that this is consistent with their existing approvals. Results will be disseminated via scientific forums including peer-reviewed publications and presentations at international conferences. TRIAL REGISTRATION NUMBER: CRD42016033236.

PY - 2016 SN - 2044-6055 (Electronic)
2044-6055 (Linking) EP - e012723 T2 - BMJ Open TI - Text2PreventCVD: protocol for a systematic review and individual participant data meta-analysis of text message-based interventions for the prevention of cardiovascular diseases VL - 6 Y2 - FY17 ER -