TY - JOUR AU - Köhler S AU - O'Brien JT AU - Mead GE AU - Hackett M AB -

The most common neuropsychiatric outcomes of stroke are depression, anxiety, fatigue, and apathy, which each occur in at least 30% of patients and have substantial overlap of prevalence and symptoms. Emotional lability, personality changes, psychosis, and mania are less common but equally distressing symptoms that are also challenging to manage. The cause of these syndromes is not known, and there is no clear relation to location of brain lesion. There are important gaps in knowledge about how to manage these disorders, even for depression, which is the most studied syndrome. Further research is needed to identify causes and interventions to prevent and treat these disorders.

AD - The George Institute for Global Health, The University of Sydney, Sydney, NSW, Australia; University of Central Lancashire, Preston, UK.
Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Department of Psychiatry, University of Cambridge, Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Royal Infirmary, Edinburgh, UK. Electronic address: gillian.e.mead@ed.ac.uk. AN - 24685278 BT - Lancet Neurology DP - NLM ET - 2014/04/02 LA - eng LB - NMH M1 - 5 N1 - Hackett, Maree L
Kohler, Sebastian
O'Brien, John T
Mead, Gillian E
Review
England
Lancet Neurol. 2014 May;13(5):525-34. doi: 10.1016/S1474-4422(14)70016-X. Epub 2014 Mar 28. N2 -

The most common neuropsychiatric outcomes of stroke are depression, anxiety, fatigue, and apathy, which each occur in at least 30% of patients and have substantial overlap of prevalence and symptoms. Emotional lability, personality changes, psychosis, and mania are less common but equally distressing symptoms that are also challenging to manage. The cause of these syndromes is not known, and there is no clear relation to location of brain lesion. There are important gaps in knowledge about how to manage these disorders, even for depression, which is the most studied syndrome. Further research is needed to identify causes and interventions to prevent and treat these disorders.

PY - 2014 SN - 1474-4465 (Electronic) - 1474-4422 (Linking) SP - 525 EP - 34 T2 - Lancet Neurology TI - Neuropsychiatric outcomes of stroke VL - 13 ER -