03067nas a2200469   4500000000100000008004100001653001100042653001100053653000900064653000900073653001500082653002200097653001600119653002600135653003000161653001100191653001700202653001600219653002500235653001900260653002400279653002200303653002100325653002600346100001600372700001800388700002000406700002000426700002000446700001700466700001900483700002000502700002000522700001600542700001700558700003000575245008700605300001200692490000700704520187200711022001402583       2016                            d10aFemale10aHumans10aAged10aMale10aOdds Ratio10aTreatment Outcome10aMiddle Aged10aDisability Evaluation10aSeverity of Illness Index10aStroke10aTime Factors10aAge Factors10aRecovery of Function10aBrain Ischemia10aCerebral Hemorrhage10aAged, 80 and over10aEarly Ambulation10aStroke Rehabilitation1 aMoodie Marj1 aThrift Amanda1 aChurilov Leonid1 aLindley Richard1 aBernhardt Julie1 aEllery Fiona1 aCollier Janice1 aChamberlain Jan1 aLanghorne Peter1 aDewey Helen1 aDonnan Geoff1 aAVERT Collaboration Group00aPrespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT).  a2138-450 v863 a<p>
<b>OBJECTIVE: </b>Our prespecified dose-response analyses of A Very Early Rehabilitation Trial (AVERT) aim to provide practical guidance for clinicians on the timing, frequency, and amount of mobilization following acute stroke.
</p>

<p>
<b>METHODS: </b>Eligible patients were aged ≥18 years, had confirmed first (or recurrent) stroke, and were admitted to a stroke unit within 24 hours of stroke onset. Patients were randomized to receive very early and frequent mobilization, commencing within 24 hours, or usual care. We used regression analyses and Classification and Regression Trees (CART) to investigate the effect of timing and dose of mobilization on efficacy and safety outcomes, irrespective of assigned treatment group.
</p>

<p>
<b>RESULTS: </b>A total of 2,104 patients were enrolled, of whom 2,083 (99.0%) were followed up at 3 months. We found a consistent pattern of improved odds of favorable outcome in efficacy and safety outcomes with increased daily frequency of out-of-bed sessions (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.09 to 1.18, p &lt; 0.001), keeping time to first mobilization and mobilization amount constant. Increased amount (minutes per day) of mobilization reduced the odds of a good outcome (OR 0.94, 95% CI 0.91 to 0.97, p &lt; 0.001). Session frequency was the most important variable in the CART analysis, after prognostic variables age and baseline stroke severity.
</p>

<p>
<b>CONCLUSION: </b>These data suggest that shorter, more frequent mobilization early after acute stroke is associated with greater odds of favorable outcome at 3 months when controlling for age and stroke severity.
</p>

<p>
<b>CLASSIFICATION OF EVIDENCE: </b>This study provides Class III evidence that shorter, more frequent early mobilization improves the chance of regaining independence after stroke.
</p>
  a1526-632X