01091nas a2200169 4500000000100000008004100001100001400042700001500056700001200071700001400083245004000097250001500137300001100152490000700163520070200170020004900872 2014 d1 aKöhler S1 aO'Brien JT1 aMead GE1 aHackett M00aNeuropsychiatric outcomes of stroke a2014/04/02 a525-340 v133 a

The most common neuropsychiatric outcomes of stroke are depression, anxiety, fatigue, and apathy, which each occur in at least 30% of patients and have substantial overlap of prevalence and symptoms. Emotional lability, personality changes, psychosis, and mania are less common but equally distressing symptoms that are also challenging to manage. The cause of these syndromes is not known, and there is no clear relation to location of brain lesion. There are important gaps in knowledge about how to manage these disorders, even for depression, which is the most studied syndrome. Further research is needed to identify causes and interventions to prevent and treat these disorders.

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